Millipore's Amicon Ultra-15 centrifugal filter device (10K molecular weight cut-off) has been granted a European Union CE Mark indicating it meets all essential requirements set forth in the In-vitro Diagnostics Directive.
The measurement of specific proteins is important for the diagnosis and management of disease states. In some cases, the proteins of interest (such as macromolecules found in biological fluids including serum, urine and spinal fluid) are present in low abundance and require concentration prior to clinical laboratory analysis. Millipore's Amicon Ultra-15 centrifugal filter unit provides ultra-fast, high-recovery purification and concentration of these proteins. They can be valuable prognostic indicators of specific abnormalities, such as tumour cells.
Sample volumes up to 15 mL can be concentrated in around 10-15 minutes with negligible loss of sample.
The device's Ultracel regenerated cellulose membrane minimises adsorption of the macromolecules and provides high recovery of fully functional proteins (typically above 90%).
The centrifugal filters are compatible with most rotor types and allow for direct pipettor access, which eliminates the need for an extra processing step. The device is available in packs of eight, 24, and 96 filter units, which come assembled with centrifuge tubes and caps.
Millipore also offers the CE-marked Amicon Ultra-4 centrifugal filter device for sample volumes up to 4 mL.