Pharma 5.0

Lilly partners with NVIDIA to build pharma’s most powerful AI supercomputer for faster drug discovery

Published: 3-Nov-2025

Eli Lilly has joined forces with NVIDIA to create the world’s most powerful pharmaceutical supercomputer, designed to accelerate AI-driven medicine discovery and manufacturing — all while running entirely on renewable energy

Eli Lilly has announced that it is partnering with NVIDIA to build the most powerful supercomputer owned and operated by a pharmaceutical company.

The supercomputer will power an "AI factory," a specialised computing infrastructure that manages the entire AI lifecycle from data ingestion and training to fine-tuning and high-volume inference.

"Lilly's mission is to make life better for people around the world and today that requires excellence not just in science but also in technology," said Diogo Rau, Executive Vice President and Chief Information and Digital Officer at Lilly.

"I don't believe any other company in our industry is doing what we do at this scale."

"As a 150-year-old medicine company, one of our most powerful assets is decades of data."

"With purpose-built AI models and AI, we can set a new scientific standard that accelerates innovation to deliver medicines to more patients, faster."


The supercomputer is the world's first NVIDIA DGX SuperPOD with DGX B300 systems.

It is powered by more than 1000 B300 GPUs on a unified networking fabric, meaning communication across GPUs, storage and related systems runs on just one high-speed network.

Scientists will be able to train AI models on millions of experiments to test potential medicines, dramatically expanding the scope and sophistication of drug discovery efforts.

A number of these proprietary AI models will be available on Lilly TuneLab, a collaborative federated AI/ML drug discovery platform designed to expand access to advanced discovery tools across the biopharma ecosystem.

TuneLab will continue evolving its suite of available models, including the addition of workflows that incorporate select NVIDIA Clara open-source models.


Beyond discovery, Lilly plans to leverage the supercomputer to shorten development cycles and help bring medicines to people faster.

New scientific AI agents can support researchers in reasoning, planning and collaborating across digital and physical environments.

With advanced medical imaging, scientists benefit from a clearer view of how diseases progress and can develop new biomarkers for more personalised care.

Manufacturing processes can benefit from digital twins together with NVIDIA's robotic technologies to improve production efficiency and reduce downtime.

"The AI industrial revolution will have its most profound impact on medicine, transforming how we understand biology," said Kimberly Powell, Vice President of Health Care at NVIDIA.

"Modern AI factories are becoming the new instrument of science — enabling the shift from trial-and-error discovery to a more intentional design of medicines."

"With its deep scientific heritage and commitment to innovation, Lilly stands as a global leader at the forefront of this new era of medical discovery."

"Lilly is shifting from using AI as a tool to embracing it as a scientific collaborator," said Thomas Fuchs, Senior Vice President and Chief AI Officer at Lilly.

"By embedding intelligence into every layer of our workflows, we're opening the door to a new kind of enterprise: one that learns, adapts and improves with every data point."

"This isn't just about speed, but rather interrogating biology at scale, deepening our understanding of disease and translating that knowledge into meaningful advances for people served by Lilly medicines as well as the broader life sciences ecosystem."


In accordance with Lilly's existing sustainability commitments, the supercomputer will run on 100% renewable electricity within existing Lilly facilities and use Lilly's chilled water infrastructure for liquid cooling.

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