New cryogenic reactor from Rhodia ChiRex

Published: 21-Nov-2001


Rhodia ChiRex, a leading manufacturer of cGMP intermediates and APIs, has implemented a new cryogenic reactor with the help of ABB Eutech for project management, design and construction.

The cryogenic reactor complements existing technologies in the company's general-purpose plant at its Holmes Chapel site in Cheshire, UK. The equipment provides facilities for process establishment and small-scale manufacture of products, including cryogenic steps, and leads to the larger cryogenic facilities on the company's full-scale cGMP manufacturing facilities.

Cryogenic reaction capability provides suitable conditions in which to carry out reactions involving highly reactive species, achieving a controlled and more selective conversion by the use of temperatures as low as -90oC. The low temperature allows reactions to progress via intermediates that would not form at higher temperatures.

'The reactor provided is designed as a general-purpose cryogenic unit capable of operating from -90oC to +120oC. Cryogenic temperatures are achieved using liquid nitrogen, with gaseous nitrogen off-gases being recovered for other uses within the site VOC abatement and inertion facilities,' said Jos Marshall, ABB Eutech's project manager.

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