Automating production of compound libraries

The aim of the described work was to develop a continuous flow protocol to replace traditional 2-step synthesis and to examine the scope of this methodology

The FlowSyn from Uniqsis is a compact integrated continuous flow reactor system designed for easy, safe and efficient operation.

Application Note 29 describes an efficient continuous flow synthesis protocol to create a new library of pyrazoles developed by chemists at GalChimia (Coruna, Spain) on a FlowSyn continuous flow reactor system.

The aim of the described work was to develop a continuous flow protocol to replace traditional 2-step synthesis and to examine the scope of this methodology. The authors of the application note demonstrate how, using the FlowSyn system, various conditions could be quickly evaluated under flow-through conditions thereby facilitating rapid reaction optimisation. Using the FlowSyn system, useful quantities of various pyrazoles could be prepared in less than 1 hour each.

The CEO of GalChimia said: "Taking in account all the data we gathered in the different experiments, we can conclude that the tandem synthesis of pyrazoles using the Uniqsis FlowSyn system offers a general, high-yielding method to prepare these compounds, which can be used with many different substrates".

The FlowSyn range includes models for performing single or multiple homogeneous or heterogeneous reactions, manually or automatically. Typical examples of flow chemistry applications include hydrogenation, nitration, bromination, metalation, molecular rearrangements and synthesis of compounds such as dihyropyridine, indole, pyrazole, quinolinone and benzimidazole.

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