Choosing a benchtop high pressure homogeniser


For applications including cellular lysis, emulsification, particle size reduction, liposome formation and more

The Avestin range of high pressure homogenisers from Biopharma Process Systems offer high pressures adjustable to 45,000psi.

The process itself involves subjecting a fluid sample to the high pressures via forced passage through a narrow orifice. As the sample exits the orifice, forces such as high shear rupture the cell/particle, with preservation of desired product integrity.

The Emulsiflex design ensures there are no “O” rings or gaskets in the entire path of the product. This means less risk of contamination, easier cleaning and no leakage.

Key characteristics of the available Avestin benchtop models are described below.

The Avestin B15

The B15 model is for small and/or high-value samples. Its pneumatically-powered design means that no electrical power is required for functionality. Its pump design ensures silent operation.

It has a adjustable pressures of up to 45,000psi with a sample capacity of 3ml–15ml.

The Avestin C5

Pneumatically-powered, this system has a processing rate of 1-5L/hr, dependent on the induced homogenising pressure.

It has adjustable pressures of up to 30,000psi with stringent sample temperature control for temperature-sensitive products. Sample temperature control mechanisms may be installed at the instrument inlet or outlet.

The entire system can be immersed in a water/ice bath, as there are no electrical connections. It is also suitable for cold room use.

The C5 has a a minimum sample volume of 7ml and a holdback volume of <1ml.

The Avestin C3

The C3 has a consistent flow rate of 3L/hr. It has an electrically-driven high pressure pump, with minimal need for compressed air/gas. Homogenising pressures can be adjusted to 30,000psi.

The C3 is similar to the C5 in that sample temperature control mechanisms can be installed at the inlet or outlet, plus the same cold room suitability.

The C3 has a minimum sample volume of 10ml, and a holdback volume of <1ml.

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All Avestin systems are GMP suitable.