The rise of targeted modalities in pharmaceutical development

Published: 31-Mar-2025

Targeted modalities represent a significant evolution in drug development, reports Anshul Gupte, Vice President of Pharmaceutical Development at PCI Pharma Services. They distinguish themselves from traditional small molecules and biologics by focusing on precise mechanisms of action

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These therapies are designed to bind specifically to receptors or biological targets, thereby ensuring a more directed and effective treatment while reducing systemic exposure and unintended side-effects.

Two of the leading targeted modalities, antibody drug conjugates (ADCs) and targeted protein degraders (TPDs), are poised to experience significant market growth in the future.

The ADC market, for instance, is projected to increase from $7.6 billion in 2022 to $19.8 billion by 2028, growing at a CAGR of 15.2% during that period.1

Similarly, the global TPD market was valued at approximately $541.98 million in 2024 and is expected to reach $3.55 billion by 2034, growing at a CAGR of 20.7% during the forecast period.2

Although targeted modalities are most commonly associated with oncology, their application is expanding into other disease states where specific pathways can be leveraged for therapeutic intervention. 

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