Several chemicals in fragrance products such as perfumes or shower gels can cause unwanted allergic reaction. These compounds are defined as potential allergens, of which 24 chemicals, plus 2 isomers, are regulated by the EU.
When analysing cosmetic products, they can be subdivided into leave on (e.g. perfumes, cremes) or rinse off (shower gels, soaps etc.). Shimadzu used a GCMS with two columns of different polarity to avoid coelutions. The most efficient setup is to use two columns connected to two different split/splitless injectors, which are mounted into the interface of one mass spectrometric detector.
The scientific committee on consumer safety proposed to extend the list, as documented (SCCS/1459/11).
This report analyses 59 chemical substances using a twin-line (unpolar and WAX) GCMSMS method to apply maximum selectivity when selecting optimised multi reaction monitoring (MRM).
Click here to access the full report.
