The significance of identifying API impurities in GLP-1 drugs and its impact on pharmaceutical research

Published: 30-Apr-2025

The identification and control of active pharmaceutical ingredient (API) impurities is critical to ensure the safety, efficacy and stability of GLP-1 (glucagon-like peptide-1) drugs such as semaglutide and liraglutide

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These drugs, used to treat type 2 diabetes and obesity, are particularly vulnerable to contamination because of their complex structure and manufacturing processes, reports Bryan Tackett, Product Marketing Manager Brand & Global Communications, Phenomenex.

The presence of foreign matter can greatly affect their therapeutic performance, making impurity profiling a crucial element of drug development and production. 

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